A Scoping Review pharmacology of Andrographis paniculata

Abstract

Andrographis paniculata, commonly known as sambiloto, is a medicinal plant that has long been used in traditional medicine for its anti-inflammatory and antibacterial properties. This study aims to evaluate the therapeutic potential of A. paniculata, with a particular focus on its bioactive compound andrographolide, its pharmacological activities, and advances in formulation technology. A systematic literature review method was employed to analyze articles published between 2010 and 2024. Articles were selected based on their relevance to the fields of pharmacy, pharmacology, and pharmaceutical botany. The findings indicate that andrographolide exhibits anti-inflammatory, anticancer, antidiabetic, and immunomodulatory activities. The development of nano-based formulations, such as Self-Microemulsifying Drug Delivery Systems (SMEDDS), has been shown to enhance the solubility and efficacy of andrographolide. In conclusion, although A. paniculata demonstrates significant therapeutic potential, further research is needed to address challenges such as low bioavailability and the toxicity of its active compounds. This article also emphasizes the importance of clinical trials to ensure the safety and efficacy of A. paniculata-based formulations in medical applications.