Nephroprotective Activity Test of Ethyl Acetate Fraction of Breadfruit Leaves (Artocarpus altilis) Against Male White Rats of Wistar Strain

Abstract

Breadfruit leaves (Artocarpus altilis) contain a variety of compounds, one of which is flavonoids that have the potential to be nefroprotective. The purpose of this study was to test the nephroprotective activity of ethyl acetate fraction of breadfruit leaves (Artocarpus altilis) in male white rats. This study is experimental with a pre-test and post-test control group design. The subjects were male white rats who were grouped into 6 groups, namely the normal group, the negative group, the comparator drug group, the ethyl acetate fraction group at a dose of 100 mg/kg BB, the ethyl acetate fraction group at a dose of 200 mg/kg BB, and the ethyl acetate fraction group at a dose of 400 mg/kg BB. The average results of each group for the parameters for measuring serum creatinine levels were 0.5 mg/dl, 2.3 mg/dl, 0.9 mg/dl, 2.2 mg/dl, 1.8 mg/dl, and 1.4 mg/dl. The conclusion of this study is that the ethyl acetate fraction of breadfruit leaves has a nephroprotective activity that can prevent an increase in creatinine levels in mice that have been induced with sodium oxalate. The dose of ethyl acetate fraction of 400 mg/kg BB showed the most effective dose in preventing increased creatinine levels.